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ea0026oc1.3 | Thyroid/Adrenal | ECE2011

Maternal thyroid dysfunction during pregnancy and thyroid function of the offspring at the age of 16 years

Pakkila Fanni , Mannisto Tuija , Bloigu Aini , Vaarasmaki Marja , Hartikainen Anna-Liisa , Ruokonen Aimo , Pouta Anneli , Jarvelin Marjo-Riitta , Surcel Helja-Marja , Suvanto Eila

Introduction: Foetus is dependent on maternal thyroid hormone production during the first trimester. Thus, maternal thyroid dysfunction and thyroid antibodies may affect thyroid function of the offspring.Subjects and methods: We studied a subcohort (n=2000 motherchild-pairs) from a prospective population-based Northern Finland Birth Cohort 1986 (singleton births, total n=9247) covering data throughout pregnancy, childhood and adolesce...

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ea0015p288 | Reproduction | SFEBES2008

Association of variants within the fat mass and obesity-associated (FTO) gene and polycystic ovary syndrome

Barber Thomas , Bennett Amanda , Groves Christopher , Sovio Ulla , Ruokonen Aimo , Martikainen Hannu , Pouta Anneli , Hartikainen Anna-Liisa , Elliott Paul , Lindgren Cecilia , Freathy Rachel , Koch Kirsten , Ouwehand Willem , Karpe Fredrik , Conway Gerard , Wass John , Jarvelin Marjo-Riitta , Franks Stephen , McCarthy Mark

Background: Obesity plays an important role in the aetiology of polycystic ovary syndrome (PCOS). Variants in the fat-mass and obesity-associated (FTO) gene have recently been shown to influence adiposity and predispose to common obesity (Frayling et al., Science 2007 316 889894).Aim: Our aim was to establish whether FTO variants are also implicated in PCOS-susceptibility.Methods: A genetic ...

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Endocrine Abstracts

Maternal thyroid dysfunction during pregnancy and thyroid function of the offspring at the age of 16 years

Association of variants within the fat mass and obesity-associated (FTO) gene and polycystic ovary syndrome

BiosciAbstracts